Preparation and evaluation of rotigotine-loaded implant for the treatment of Parkinson’s disease and its evolution study

PURPOSE: To develop rotigotine-loaded implants (RI) to achieve continuous release of rotigotine for long duration for the treatment of Parkinson’s disease (PD). METHODS: RI was prepared by hot-melt extrusion method using poly (lactide-co-glycolide) (PLGA) as the matrix. In vitro drug release was opt...

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Dettagli Bibliografici
Pubblicato in:Saudi Pharm J
Autori principali: Wang, Aiping, Liu, Yanxiang, Liang, Rongcai, Zhang, Xuemei, Sun, Kaoxiang, Wu, Zimei, Liu, Wanhui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
Soggetti:
Pharmaceutical Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4881155/
https://ncbi.nlm.nih.gov/pubmed/27275128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2016.04.022
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