Lactoferrin-modified rotigotine nanoparticles for enhanced nose-to-brain delivery: LESA-MS/MS-based drug biodistribution, pharmacodynamics, and neuroprotective effects

INTRODUCTION: Efficient delivery of rotigotine into the brain is crucial for obtaining maximum therapeutic efficacy for Parkinson’s disease (PD). Therefore, in the present study, we prepared lactoferrin-modified rotigotine nanoparticles (Lf-R-NPs) and studied their biodistribution, pharmacodynamics,...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Principais autores: Yan, Xiuju, Xu, Lixiao, Bi, Chenchen, Duan, Dongyu, Chu, Liuxiang, Yu, Xin, Wu, Zimei, Wang, Aiping, Sun, Kaoxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5768421/
https://ncbi.nlm.nih.gov/pubmed/29391788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S151475
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