Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

BACKGROUND: Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, and is generally resolved by the nucleotide excision repair (NER) repair mechan...

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Dettagli Bibliografici
Pubblicato in:Clin Epigenetics
Autori principali: Wang, Yong, Li, Fei, Zhang, Guowei, Kang, Lihua, Guan, Huaijin
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880862/
https://ncbi.nlm.nih.gov/pubmed/27231489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0229-y
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