Ultraviolet-B induces ERCC6 repression in lens epithelium cells of age-related nuclear cataract through coordinated DNA hypermethylation and histone deacetylation

BACKGROUND: Ultraviolet-B (UVB) exposure attributes to the formation of age-related nuclear cataract (ARNC), which is mediated with DNA damage. DNA damage, an important factor for pathogenesis of ARNC, is induced by UVB, and is generally resolved by the nucleotide excision repair (NER) repair mechan...

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Gepubliceerd in:Clin Epigenetics
Hoofdauteurs: Wang, Yong, Li, Fei, Zhang, Guowei, Kang, Lihua, Guan, Huaijin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2016
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Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880862/
https://ncbi.nlm.nih.gov/pubmed/27231489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-016-0229-y
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