DELETION OR INHIBITION OF THE OXYGEN SENSOR PHD1 PROTECTS AGAINST ISCHEMIC STROKE VIA REPROGRAMMING OF NEURONAL METABOLISM

The oxygen-sensing prolyl hydroxylase domain proteins (PHDs) regulate cellular metabolism, but their role in neuronal metabolism during stroke is unknown. Here we report that PHD1 deficiency provides neuroprotection in a murine model of permanent brain ischemia. This was not due to an increased coll...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Quaegebeur, Annelies, Segura, Inmaculada, Schmieder, Roberta, Verdegem, Dries, Decimo, Ilaria, Bifari, Francesco, Dresselaers, Tom, Eelen, Guy, Ghosh, Debapriva, Schoors, Sandra, Janaki Raman, Sudha Rani, Cruys, Bert, Govaerts, Kristof, De Legher, Carla, Bouché, Ann, Schoonjans, Luc, Ramer, Matt S., Hung, Gene, Bossaert, Goele, Cleveland, Don W., Himmelreich, Uwe, Voets, Thomas, Lemmens, Robin, Bennett, C. Frank, Robberecht, Wim, De Bock, Katrien, Dewerchin, Mieke, Fendt, Sarah-Maria, Ghesquière, Bart, Carmeliet, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880550/
https://ncbi.nlm.nih.gov/pubmed/26774962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2015.12.007
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