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TAD disruption as oncogenic driver
Topologically Associating Domains (TADs) are conserved during evolution and play roles in guiding and constraining long-range regulation of gene expression. Disruption of TAD boundaries results in aberrant gene expression by exposing genes to inappropriate regulatory elements. Recent studies have sh...
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| Publicado en: | Curr Opin Genet Dev |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4880504/ https://ncbi.nlm.nih.gov/pubmed/27111891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2016.03.008 |
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