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The Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis

The mechanisms by which lanthipeptide synthetases control the order in which they catalyze multiple chemical processes are poorly understood. The lacticin 481 synthetase (LctM) cleaves eight chemical bonds and forms six new chemical bonds in a controlled and ordered process. Two general mechanisms h...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Thibodeaux, Christopher J., Wagoner, Joshua, Yu, Yi, van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880487/
https://ncbi.nlm.nih.gov/pubmed/27123925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b00163
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