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Mutants of the Zinc Ligands of Lacticin 481 Synthetase Retain Dehydration Activity but Have Impaired Cyclization Activity

Lantibiotics are ribosomally synthesized and post-translationally modified peptide antibiotics. The modifications involve dehydration of Ser and Thr residues to generate dehydroalanines and dehydrobutyrines, followed by intramolecular attack of cysteines onto the newly formed dehydro amino acids to...

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Main Authors: Paul, Moushumi, Patton, Gregory C., van der Donk, Wilfred A.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2517114/
https://ncbi.nlm.nih.gov/pubmed/17480057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi7000104
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