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Alteration of a protease-sensitive region of Pseudomonas exotoxin prolongs its survival in the circulation of mice.

Pseudomonas exotoxin A (PE) is a single-chain 66-kDa polypeptide that kills eukaryotic cells by ADP-ribosylation of translational elongation factor 2. PE is composed of three major structural domains whose functions are binding of cells (I), translocation (II), and ADP-ribosylation (III). Here we de...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Brinkmann, U, Pai, L H, FitzGerald, D J, Pastan, I
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48804/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1557414/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.3065
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