17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats

Sepsis is a systemic inflammatory disorder, accompanied with elevated oxidative stress, leading to multiple organ dysfunction syndrome (MODS), and disseminated intravascular coagulation. 17-Dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein (HSP) 90 inhibitor, has been...

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Pubblicato in:PLoS One
Autori principali: Wang, Yi-Li, Shen, Hsin-Hsueh, Cheng, Pao-Yun, Chu, Yen-Ju, Hwang, Hwong-Ru, Lam, Kwok-Keung, Lee, Yen-Mei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4880344/
https://ncbi.nlm.nih.gov/pubmed/27224288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155583
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