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Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein.

Extracellular deposition of the beta/A4 amyloid peptide is a characteristic feature of the brain in patients with Alzheimer disease. beta/A4 amyloid is derived from the amyloid precursor protein (APP), an integral membrane protein that exists as three major isoforms (APP695, APP751, and APP770). Sec...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Caporaso, G L, Gandy, S E, Buxbaum, J D, Ramabhadran, T V, Greengard, P
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48802/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1557413/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.3055
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