MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer’s disease

MicroRNA-146a is upregulated in the brains of patients with Alzheimer’s disease (AD). Here, we show that the rho-associated, coiled-coil containing protein kinase 1 (ROCK1) is a target of microRNA-146a in neural cells. Knockdown of ROCK1 mimicked the effects of microRNA-146a overexpression and induc...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Gang, Huang, Yue, Wang, Li-Ling, Zhang, Yong-Fang, Xu, Jing, Zhou, Yi, Lourenco, Guinevere F., Zhang, Bei, Wang, Ying, Ren, Ru-Jing, Halliday, Glenda M., Chen, Sheng-Di
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879631/
https://ncbi.nlm.nih.gov/pubmed/27221467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26697
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