Barrier-Independent, Fitness-Associated Differences in Sofosbuvir Efficacy against Hepatitis C Virus

Sofosbuvir displays a high phenotypic barrier to resistance, and it is a component of several combination therapies for hepatitis C virus (HCV) infections. HCV fitness can be a determinant of decreased sensitivity to direct-acting antiviral agents such as telaprevir or daclatasvir, but fitness-depen...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Gallego, Isabel, Sheldon, Julie, Moreno, Elena, Gregori, Josep, Quer, Josep, Esteban, Juan Ignacio, Rice, Charles M., Domingo, Esteban, Perales, Celia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879421/
https://ncbi.nlm.nih.gov/pubmed/27067341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00581-16
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