Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic stress response and also represses inflammation. However, the mechanisms how Nrf2 alleviates inflammation are still unclear. Here, we demonstrate that Nrf2 interferes with lipopolysaccharide-induced transcriptional upr...

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Pubblicato in:Nat Commun
Autori principali: Kobayashi, Eri H., Suzuki, Takafumi, Funayama, Ryo, Nagashima, Takeshi, Hayashi, Makiko, Sekine, Hiroki, Tanaka, Nobuyuki, Moriguchi, Takashi, Motohashi, Hozumi, Nakayama, Keiko, Yamamoto, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4879264/
https://ncbi.nlm.nih.gov/pubmed/27211851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11624
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