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Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats

PURPOSE: The K(+) channel blocker 4-aminopyridine (4AP) induces epileptiform synchronization in brain slices maintained in vitro without interfering with γ-aminobutyric acid (GABA)(A) receptor–mediated inhibition and, actually, even enhancing it. The hypothesis that similar electrographic epileptifo...

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Bibliografische gegevens
Gepubliceerd in:Epilepsia
Hoofdauteurs: Lévesque, Maxime, Salami, Pariya, Behr, Charles, Avoli, Massimo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878895/
https://ncbi.nlm.nih.gov/pubmed/23521339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/epi.12041
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