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Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.

2-Chlorodeoxyadenosine (CdA) is active in chronic lymphocytic leukemia, hairy-cell leukemia, and low-grade lymphomas. In part, this spectrum of activity may be attributable to the selective toxicity of CdA to nondividing lymphocytes and monocytes. However, CdA is unstable at acidic pH and is degrade...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carson, D A, Wasson, D B, Esparza, L M, Carrera, C J, Kipps, T J, Cottam, H B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48785/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1348362/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2970
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