Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.

2-Chlorodeoxyadenosine (CdA) is active in chronic lymphocytic leukemia, hairy-cell leukemia, and low-grade lymphomas. In part, this spectrum of activity may be attributable to the selective toxicity of CdA to nondividing lymphocytes and monocytes. However, CdA is unstable at acidic pH and is degrade...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Carson, D A, Wasson, D B, Esparza, L M, Carrera, C J, Kipps, T J, Cottam, H B
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1992
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1348362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2970
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