Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.

2-Chlorodeoxyadenosine (CdA) is active in chronic lymphocytic leukemia, hairy-cell leukemia, and low-grade lymphomas. In part, this spectrum of activity may be attributable to the selective toxicity of CdA to nondividing lymphocytes and monocytes. However, CdA is unstable at acidic pH and is degrade...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Carson, D A, Wasson, D B, Esparza, L M, Carrera, C J, Kipps, T J, Cottam, H B
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1992
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48785/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1348362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.7.2970
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