Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits

Electron tomography is an increasingly powerful method to study the detailed architecture of macromolecular complexes or cellular structures. Applied to amyloid deposits formed in a cell culture model of systemic amyloid A amyloidosis, we could determine the structural morphology of the fibrils dire...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kollmer, Marius, Meinhardt, Katrin, Haupt, Christian, Liberta, Falk, Wulff, Melanie, Linder, Julia, Handl, Lisa, Heinrich, Liesa, Loos, Cornelia, Schmidt, Matthias, Syrovets, Tatiana, Simmet, Thomas, Westermark, Per, Westermark, Gunilla T., Horn, Uwe, Schmidt, Volker, Walther, Paul, Fändrich, Marcus
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2016
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878484/
https://ncbi.nlm.nih.gov/pubmed/27140609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1523496113
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