Nuclear pore complex remodeling by p75(NTR) cleavage controls TGF-β signaling and astrocyte functions

Astrocytes play critical roles in neuronal activity and inhibition of regeneration. Here we show that the cleaved p75 neurotrophin receptor (p75(NTR)) is a component of the nuclear pore complex (NPC) required for glial scar formation and reduced gamma oscillations in mice via regulation of TGF-β sig...

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Veröffentlicht in:Nat Neurosci
Hauptverfasser: Schachtrup, Christian, Ryu, Jae Kyu, Mammadzada, Könül, Khan, Abdullah S., Carlton, Peter M., Perez, Alex, Christian, Frank, Le Moan, Natacha, Vagena, Eirini, Baeza-Raja, Bernat, Rafalski, Victoria, Chan, Justin P., Nitschke, Roland, Houslay, Miles D., Ellisman, Mark H., Wyss-Coray, Tony, Palop, Jorge J., Akassoglou, Katerina
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4878404/
https://ncbi.nlm.nih.gov/pubmed/26120963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.4054
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