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Oxygen-Dependent Cleavage of the p75 Neurotrophin Receptor Triggers Stabilization of HIF-1α

Homeostatic control of oxygen availability allows cells to survive oxygen deprivation. Although the transcription factor hypoxia-inducible factor 1α (HIF-1α) is the main regulator of the hypoxic response, the upstream mechanisms required for its stabilization remain elusive. Here, we show that p75 n...

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Detalhes bibliográficos
Main Authors: Le Moan, Natacha, Houslay, Daniel M., Christian, Frank, Houslay, Miles D., Akassoglou, Katerina
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212815/
https://ncbi.nlm.nih.gov/pubmed/22055192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.033
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