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Next-generation proteasome inhibitor MLN9708 sensitizes breast cancer cells to doxorubicin-induced apoptosis

Doxorubicin (Dox), one of the most effective chemotherapy drug for cancer treatment, is limited by its severe side effects and chemoresistance. Dox induces DNA damage and leads to significant proteomic changes in the cancer cells, which makes the ubiquitin-proteasome system a potential target to enh...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Wang, Hao, Yu, Yang, Jiang, Zheng, Cao, Wen-Ming, Wang, Zhenyu, Dou, Jun, Zhao, Yanling, Cui, Yunfu, Zhang, Hong
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877646/
https://ncbi.nlm.nih.gov/pubmed/27217076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26456
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