Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

BACKGROUND: The search for intrinsic factors, which account for a protein's capability to act as an allergen, is ongoing. Fold stability has been identified as a molecular feature that affects processing and presentation, thereby influencing an antigen's immunologic properties. OBJECTIVE:...

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Veröffentlicht in:J Allergy Clin Immunol
Hauptverfasser: Machado, Yoan, Freier, Regina, Scheiblhofer, Sandra, Thalhamer, Theresa, Mayr, Melissa, Briza, Peter, Grutsch, Sarina, Ahammer, Linda, Fuchs, Julian E., Wallnoefer, Hannes G., Isakovic, Almedina, Kohlbauer, Vera, Hinterholzer, Arthur, Steiner, Markus, Danzer, Martin, Horejs-Hoeck, Jutta, Ferreira, Fatima, Liedl, Klaus R., Tollinger, Martin, Lackner, Peter, Johnson, Christopher M., Brandstetter, Hans, Thalhamer, Josef, Weiss, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mosby 2016
Schlagworte:
Mechanisms of Allergy and Clinical Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877439/
https://ncbi.nlm.nih.gov/pubmed/26559323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.09.026
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