Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death

Sudden unexplained death in epilepsy (SUDEP) is the most common cause of premature mortality in epilepsy and was linked to mutations in ion channels; however, genes within the channel protein interactome might also represent pathogenic candidates. Here we show that mice with partial deficiency of Se...

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發表在:Neuron
Main Authors: Qi, Yitao, Wang, Jingxiong, Bomben, Valerie C., Li, De-Pei, Chen, Shao-Rui, Sun, Hao, Xi, Yutao, Reed, John G., Cheng, Jinke, Pan, Hui-Lin, Noebels, Jeffrey L., Yeh, Edward T.H.
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877174/
https://ncbi.nlm.nih.gov/pubmed/25189211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.07.042
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