Hyper-SUMOylation of the Kv7 Potassium Channel Diminishes the M-Current Leading to Seizures and Sudden Death

Sudden unexplained death in epilepsy (SUDEP) is the most common cause of premature mortality in epilepsy and was linked to mutations in ion channels; however, genes within the channel protein interactome might also represent pathogenic candidates. Here we show that mice with partial deficiency of Se...

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Detalhes bibliográficos
Publicado no:Neuron
Main Authors: Qi, Yitao, Wang, Jingxiong, Bomben, Valerie C., Li, De-Pei, Chen, Shao-Rui, Sun, Hao, Xi, Yutao, Reed, John G., Cheng, Jinke, Pan, Hui-Lin, Noebels, Jeffrey L., Yeh, Edward T.H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877174/
https://ncbi.nlm.nih.gov/pubmed/25189211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2014.07.042
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