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Poring over two-pore channel pore mutants

Two-pore channels are members of the voltage-gated ion channel superfamily. They localise to the endolysosomal system and are likely targets for the Ca(2+) mobilising messenger NAADP. In this brief review, we relate mutagenesis of the TPC pore to a recently published homology model and discuss how p...

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Publicat a:Messenger (Los Angel)
Autors principals: Penny, Christopher J., Patel, Sandip
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876920/
https://ncbi.nlm.nih.gov/pubmed/27226934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1166/msr.2015.1044
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