Probing Gα(i1) Protein Activation at Single Amino Acid Resolution

We present comprehensive single amino acid resolution maps of the residues stabilising the human Gα(i1) subunit in nucleotide- and receptor-bound states. We generated these maps by measuring the effects of alanine mutations on the stability of Gα(i1) and of the rhodopsin-Gα(i1) complex. We identifie...

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Bibliographic Details
Published in:Nat Struct Mol Biol
Main Authors: Sun, Dawei, Flock, Tilman, Deupi, Xavier, Maeda, Shoji, Matkovic, Milos, Mendieta, Sandro, Mayer, Daniel, Dawson, Roger, Schertler, Gebhard F.X., Madan Babu, M., Veprintsev, Dmitry B.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876908/
https://ncbi.nlm.nih.gov/pubmed/26258638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3070
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