Quality control in oocytes by p63 is based on a spring-loaded activation mechanism on the molecular and cellular level

Mammalian oocytes are arrested in the dictyate stage of meiotic prophase I for long periods of time, during which the high concentration of the p53 family member TAp63α sensitizes them to DNA damage-induced apoptosis. TAp63α is kept in an inactive and exclusively dimeric state but undergoes rapid ph...

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Pubblicato in:eLife
Autori principali: Coutandin, Daniel, Osterburg, Christian, Srivastav, Ratnesh Kumar, Sumyk, Manuela, Kehrloesser, Sebastian, Gebel, Jakob, Tuppi, Marcel, Hannewald, Jens, Schäfer, Birgit, Salah, Eidarus, Mathea, Sebastian, Müller-Kuller, Uta, Doutch, James, Grez, Manuel, Knapp, Stefan, Dötsch, Volker
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2016
Soggetti:
Biophysics and Structural Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876613/
https://ncbi.nlm.nih.gov/pubmed/27021569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.13909
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