TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits12

Transcription factor EB (TFEB) was recently shown to be a master regulator of autophagy lysosome pathway. Here, we successfully generated and characterized transgenic mice overexpressing flag-TFEB. Enhanced autophagy in the flag-TFEB transgenic mice was confirmed by an increase in the cellular autop...

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Foilsithe in:eNeuro
Main Authors: Wang, Hongjie, Wang, Ruizhi, Carrera, Ivan, Xu, Shaohua, Lakshmana, Madepalli K.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2016
Ábhair:
New Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876487/
https://ncbi.nlm.nih.gov/pubmed/27257626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0042-16.2016
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