Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

AIMS: Several clinical trials have confirmed the therapeutic benefit of imipenem for treatment of lung infections. There is however no knowledge of the penetration of imipenem into the lung epithelial lining fluid (ELF), the site of action relevant for lung infections. Furthermore, although the plas...

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Detalles Bibliográficos
Publicado en:Br J Clin Pharmacol
Autores principales: van Hasselt, J. G. Coen, Rizk, Matthew L., Lala, Mallika, Chavez‐Eng, Cynthia, Visser, Sandra A. G., Kerbusch, Thomas, Danhof, Meindert, Rao, Gauri, van der Graaf, Piet H.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2016
Materias:
Pharmacokinetics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876184/
https://ncbi.nlm.nih.gov/pubmed/26852277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12901
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