Pooled population pharmacokinetic model of imipenem in plasma and the lung epithelial lining fluid

AIMS: Several clinical trials have confirmed the therapeutic benefit of imipenem for treatment of lung infections. There is however no knowledge of the penetration of imipenem into the lung epithelial lining fluid (ELF), the site of action relevant for lung infections. Furthermore, although the plas...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: van Hasselt, J. G. Coen, Rizk, Matthew L., Lala, Mallika, Chavez‐Eng, Cynthia, Visser, Sandra A. G., Kerbusch, Thomas, Danhof, Meindert, Rao, Gauri, van der Graaf, Piet H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876184/
https://ncbi.nlm.nih.gov/pubmed/26852277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12901
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