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TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets
The murine thymus produces discrete γδ T cell subsets making either interferon-γ (IFN--γ) or interleukin 17 (IL-17), but the role of the TCR in this developmental process remains controversial. Here we show that mice haploinsufficient for both Cd3g and Cd3d (CD3DH, for CD3 double haploinsufficient)...
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| Publicado no: | Nat Immunol |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4875770/ https://ncbi.nlm.nih.gov/pubmed/27043412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3424 |
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