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TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

The murine thymus produces discrete γδ T cell subsets making either interferon-γ (IFN--γ) or interleukin 17 (IL-17), but the role of the TCR in this developmental process remains controversial. Here we show that mice haploinsufficient for both Cd3g and Cd3d (CD3DH, for CD3 double haploinsufficient)...

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Bibliografski detalji
Izdano u:Nat Immunol
Glavni autori: Muñoz-Ruiz, Miguel, Ribot, Julie C., Grosso, Ana R., Gonçalves-Sousa, Natacha, Pamplona, Ana, Pennington, Daniel J., Regueiro, José R., Fernández-Malavé, Edgar, Silva-Santos, Bruno
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875770/
https://ncbi.nlm.nih.gov/pubmed/27043412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3424
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