Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

BACKGROUND: Endothelin-1 (ET-1) is important in the pathogenesis of systemic sclerosis (SSc). ET-1 binds two receptors, endothelin type A (ET(A)) and endothelin type B (ET(B)). Dual ET(A)/ET(B) receptor antagonists and a selective ET(A) receptor antagonist are used clinically to treat SSc, and the e...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Akashi, Kengo, Saegusa, Jun, Sendo, Sho, Nishimura, Keisuke, Okano, Takuya, Yagi, Keiko, Yanagisawa, Masashi, Emoto, Noriaki, Morinobu, Akio
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875589/
https://ncbi.nlm.nih.gov/pubmed/27209208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1011-4
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