B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis

BACKGROUND: Rituximab (RTX) may favorably affect skin and lung fibrosis in patients with systemic sclerosis (SSc); however, the underlying molecular mechanisms remain unknown. We aimed to explore the hypothesis that RTX may mediate its antifibrotic effects by regulating the expression of Dickkopf-1...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Daoussis, Dimitrios, Tsamandas, Athanassios, Antonopoulos, Ioannis, Filippopoulou, Alexandra, Papachristou, Dionysios J., Papachristou, Nicholaos I., Andonopoulos, Andrew P., Liossis, Stamatis-Nick
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875588/
https://ncbi.nlm.nih.gov/pubmed/27208972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-016-1017-y
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