B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

INTRODUCTION: Recently, several studies assessing the clinical efficacy of rituximab (RTX) in systemic sclerosis (SSc) have reported encouraging results. We aimed at exploring whether RTX exerts its beneficial effects on fibrosis through attenuation of platelet-derived growth factor receptor (PDGFR)...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Daoussis, Dimitrios, Tsamandas, Athanassios C, Liossis, Stamatis-Nick C, Antonopoulos, Ioannis, Karatza, Elli, Yiannopoulos, Georgios, Andonopoulos, Andrew P
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446529/
https://ncbi.nlm.nih.gov/pubmed/22697462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3879
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky