B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin

INTRODUCTION: Recently, several studies assessing the clinical efficacy of rituximab (RTX) in systemic sclerosis (SSc) have reported encouraging results. We aimed at exploring whether RTX exerts its beneficial effects on fibrosis through attenuation of platelet-derived growth factor receptor (PDGFR)...

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Main Authors: Daoussis, Dimitrios, Tsamandas, Athanassios C, Liossis, Stamatis-Nick C, Antonopoulos, Ioannis, Karatza, Elli, Yiannopoulos, Georgios, Andonopoulos, Andrew P
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446529/
https://ncbi.nlm.nih.gov/pubmed/22697462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3879
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