Inhibition of SIRT6 in prostate cancer reduces cell viability and increases sensitivity to chemotherapeutics

SIRT6 is an important histone modifying protein that regulates DNA repair, telomere maintenance, energy metabolism, and target gene expression. Recently SIRT6 has been identified as a tumor suppressor and is down-regulated in certain cancer types, but not in other cancers. From deposited gene profil...

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Publicado en:Protein Cell
Autores principales: Liu, Yewei, Xie, Qian Reuben, Wang, Boshi, Shao, Jiaxiang, Zhang, Tingting, Liu, Tengyuan, Huang, Gang, Xia, Weiliang
Formato: Artigo
Lenguaje:Inglês
Publicado: Higher Education Press 2013
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875531/
https://ncbi.nlm.nih.gov/pubmed/23982738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-013-3054-5
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