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Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode

The main protease (M(pro)) plays a vital role in proteolytic processing of the polyproteins in the replicative cycle of SARS coronavirus (SARS-CoV). Dimerization of this enzyme has been shown to be indispensable for transcleavage activity. However, the auto-processing mechanism of M(pro), i.e. its o...

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Pubblicato in:Protein Cell
Autori principali: Chen, Shuai, Jonas, Felix, Shen, Can, Higenfeld, Rolf
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4875104/
https://ncbi.nlm.nih.gov/pubmed/21203998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-010-0011-4
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