The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin

Breast and ovarian cancer patients harboring BRCA1/2 germline mutations have clinically benefitted from therapy with PARP inhibitor (PARPi) or platinum compounds, but acquired resistance limits clinical impact. In this study, we investigated the impact of mutations on BRCA1 isoform expression and th...

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Udgivet i:Cancer Res
Main Authors: Wang, Yifan, Bernhardy, Andrea J., Cruz, Cristina, Krais, John J., Nacson, Joseph, Nicolas, Emmanuelle, Peri, Suraj, van der Gulden, Hanneke, van der Heijden, Ingrid, O'Brien, Shane W., Zhang, Yong, Harrell, Maribel I., Johnson, Shawn F., Candido Dos Reis, Francisco J., Pharoah, Paul D. P., Karlan, Beth, Gourley, Charlie, Lambrechts, Diether, Chenevix-Trench, Georgia, Olsson, Håkan, Benitez, Javier J., Greene, Mark H., Gore, Martin, Nussbaum, Robert, Sadetzki, Siegal, Gayther, Simon A., Kjaer, Susanne K., D'Andrea, Alan D., Shapiro, Geoffrey I., Wiest, David L., Connolly, Denise C., Daly, Mary B., Swisher, Elizabeth M., Bouwman, Peter, Jonkers, Jos, Balmaña, Judith, Serra, Violeta, Johnson, Neil
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874568/
https://ncbi.nlm.nih.gov/pubmed/27197267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0186
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