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Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome duplication in every cell cycle. To accomplish this, initiation is partitioned into two temporally discrete steps: a double hexameric MCM complex is first loaded at replication...
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| Veröffentlicht in: | Nature |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4874468/ https://ncbi.nlm.nih.gov/pubmed/25739503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14285 |
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