The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice

BACKGROUND AND AIM: Luminal nutrients stimulate enteroendocrine L cells to release gut hormones, including intestinotrophic glucagon-like peptide-2 (GLP-2). Because L cells express the bile acid receptor TGR5 and dipeptidyl peptidase-IV (DPPIV) rapidly degrades GLPs, we hypothesized that luminal TGR...

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Udgivet i:J Gastroenterol Hepatol
Main Authors: Sakanaka, Taisuke, Inoue, Takuya, Yorifuji, Naoki, Iguchi, Munetaka, Fujiwara, Kaori, Narabayashi, Ken, Kakimoto, Kazuki, Nouda, Sadaharu, Okada, Toshihiko, Kuramoto, Takanori, Ishida, Kumi, Abe, Yosuke, Takeuchi, Toshihisa, Umegaki, Eiji, Akiba, Yasutada, Kaunitz, Jonathan D., Higuchi, Kazuhide
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874188/
https://ncbi.nlm.nih.gov/pubmed/25827806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jgh.12740
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