T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine

IL-23 is a key driver of pathogenic Th17 cell responses. It has been suggested that the transcription factor T-bet is required to facilitate IL-23-driven pathogenic effector functions; however, the precise role of T-bet in intestinal T cell responses remains elusive. Here, we show that T-bet express...

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Vydáno v:Nat Commun
Hlavní autoři: Krausgruber, Thomas, Schiering, Chris, Adelmann, Krista, Harrison, Oliver J., Chomka, Agnieszka, Pearson, Claire, Ahern, Philip P., Shale, Matthew, Oukka, Mohamed, Powrie, Fiona
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4874038/
https://ncbi.nlm.nih.gov/pubmed/27193261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11627
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