Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells

Aberrant immune responses represent the underlying cause of central nervous system (CNS) autoimmunity, including multiple sclerosis (MS). Recent evidence implicated the crosstalk between coagulation and immunity in CNS autoimmunity. Here we identify coagulation factor XII (FXII), the initiator of th...

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Publicat a:Nat Commun
Autors principals: Göbel, Kerstin, Pankratz, Susann, Asaridou, Chloi-Magdalini, Herrmann, Alexander M., Bittner, Stefan, Merker, Monika, Ruck, Tobias, Glumm, Sarah, Langhauser, Friederike, Kraft, Peter, Krug, Thorsten F., Breuer, Johanna, Herold, Martin, Gross, Catharina C., Beckmann, Denise, Korb-Pap, Adelheid, Schuhmann, Michael K., Kuerten, Stefanie, Mitroulis, Ioannis, Ruppert, Clemens, Nolte, Marc W., Panousis, Con, Klotz, Luisa, Kehrel, Beate, Korn, Thomas, Langer, Harald F., Pap, Thomas, Nieswandt, Bernhard, Wiendl, Heinz, Chavakis, Triantafyllos, Kleinschnitz, Christoph, Meuth, Sven G.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873982/
https://ncbi.nlm.nih.gov/pubmed/27188843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11626
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