Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

Blood–brain barrier (BBB) disruption and transendothelial trafficking of immune cells into the central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS). Recent evidence suggests that the kallikrein-kinin and coagulation system might pa...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Göbel, Kerstin, Asaridou, Chloi-Magdalini, Merker, Monika, Eichler, Susann, Herrmann, Alexander M., Geuß, Eva, Ruck, Tobias, Schüngel, Lisa, Groeneweg, Linda, Narayanan, Venu, Schneider-Hohendorf, Tilman, Gross, Catharina C., Wiendl, Heinz, Kehrel, Beate E., Kleinschnitz, Christoph, Meuth, Sven G.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320546/
https://ncbi.nlm.nih.gov/pubmed/30559188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810020116
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