Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

Blood–brain barrier (BBB) disruption and transendothelial trafficking of immune cells into the central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS). Recent evidence suggests that the kallikrein-kinin and coagulation system might pa...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Göbel, Kerstin, Asaridou, Chloi-Magdalini, Merker, Monika, Eichler, Susann, Herrmann, Alexander M., Geuß, Eva, Ruck, Tobias, Schüngel, Lisa, Groeneweg, Linda, Narayanan, Venu, Schneider-Hohendorf, Tilman, Gross, Catharina C., Wiendl, Heinz, Kehrel, Beate E., Kleinschnitz, Christoph, Meuth, Sven G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320546/
https://ncbi.nlm.nih.gov/pubmed/30559188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810020116
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