Plasma kallikrein modulates immune cell trafficking during neuroinflammation via PAR2 and bradykinin release

Blood–brain barrier (BBB) disruption and transendothelial trafficking of immune cells into the central nervous system (CNS) are pathophysiological hallmarks of neuroinflammatory disorders like multiple sclerosis (MS). Recent evidence suggests that the kallikrein-kinin and coagulation system might pa...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Göbel, Kerstin, Asaridou, Chloi-Magdalini, Merker, Monika, Eichler, Susann, Herrmann, Alexander M., Geuß, Eva, Ruck, Tobias, Schüngel, Lisa, Groeneweg, Linda, Narayanan, Venu, Schneider-Hohendorf, Tilman, Gross, Catharina C., Wiendl, Heinz, Kehrel, Beate E., Kleinschnitz, Christoph, Meuth, Sven G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2019
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6320546/
https://ncbi.nlm.nih.gov/pubmed/30559188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810020116
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