A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...

詳細記述

保存先:
書誌詳細
出版年:Cell Metab
主要な著者: Raffan, Eleanor, Dennis, Rowena J., O’Donovan, Conor J., Becker, Julia M., Scott, Robert A., Smith, Stephen P., Withers, David J., Wood, Claire J., Conci, Elena, Clements, Dylan N., Summers, Kim M., German, Alexander J., Mellersh, Cathryn S., Arendt, Maja L., Iyemere, Valentine P., Withers, Elaine, Söder, Josefin, Wernersson, Sara, Andersson, Göran, Lindblad-Toh, Kerstin, Yeo, Giles S.H., O’Rahilly, Stephen
フォーマット: Artigo
言語:Inglês
出版事項: Cell Press 2016
主題:
Short Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
https://ncbi.nlm.nih.gov/pubmed/27157046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.012
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