A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...

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Bibliografski detalji
Izdano u:Cell Metab
Glavni autori: Raffan, Eleanor, Dennis, Rowena J., O’Donovan, Conor J., Becker, Julia M., Scott, Robert A., Smith, Stephen P., Withers, David J., Wood, Claire J., Conci, Elena, Clements, Dylan N., Summers, Kim M., German, Alexander J., Mellersh, Cathryn S., Arendt, Maja L., Iyemere, Valentine P., Withers, Elaine, Söder, Josefin, Wernersson, Sara, Andersson, Göran, Lindblad-Toh, Kerstin, Yeo, Giles S.H., O’Rahilly, Stephen
Format: Artigo
Jezik:Inglês
Izdano: Cell Press 2016
Teme:
Short Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
https://ncbi.nlm.nih.gov/pubmed/27157046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.012
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