A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...

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Vydáno v:Cell Metab
Hlavní autoři: Raffan, Eleanor, Dennis, Rowena J., O’Donovan, Conor J., Becker, Julia M., Scott, Robert A., Smith, Stephen P., Withers, David J., Wood, Claire J., Conci, Elena, Clements, Dylan N., Summers, Kim M., German, Alexander J., Mellersh, Cathryn S., Arendt, Maja L., Iyemere, Valentine P., Withers, Elaine, Söder, Josefin, Wernersson, Sara, Andersson, Göran, Lindblad-Toh, Kerstin, Yeo, Giles S.H., O’Rahilly, Stephen
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2016
Témata:
Short Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
https://ncbi.nlm.nih.gov/pubmed/27157046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.012
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