A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the β-MSH and β-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposi...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Raffan, Eleanor, Dennis, Rowena J., O’Donovan, Conor J., Becker, Julia M., Scott, Robert A., Smith, Stephen P., Withers, David J., Wood, Claire J., Conci, Elena, Clements, Dylan N., Summers, Kim M., German, Alexander J., Mellersh, Cathryn S., Arendt, Maja L., Iyemere, Valentine P., Withers, Elaine, Söder, Josefin, Wernersson, Sara, Andersson, Göran, Lindblad-Toh, Kerstin, Yeo, Giles S.H., O’Rahilly, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873617/
https://ncbi.nlm.nih.gov/pubmed/27157046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.04.012
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