New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis

Benzo(a)pyrene (BaP) is a ubiquitous carcinogen resulting from incomplete combustion of organic compounds and also present at high levels in cigarette smoke. A wide range of biological effects has been attributed to BaP and its genotoxic metabolite BPDE, but the contribution to BaP toxicity of inter...

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Dades bibliogràfiques
Publicat a:Arch Toxicol
Autors principals: Souza, Terezinha, Jennen, Danyel, van Delft, Joost, van Herwijnen, Marcel, Kyrtoupolos, Soterios, Kleinjans, Jos
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2015
Matèries:
Organ Toxicity and Mechanisms
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873527/
https://ncbi.nlm.nih.gov/pubmed/26238291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-015-1572-z
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