Melanoma cells block PEDF production in fibroblasts to induce the tumor-promoting phenotype of cancer-associated fibroblasts

Loss of pigment epithelium-derived factor (PEDF, SERPINF1) in cancer cells is associated with poor prognosis and metastasis, but the contribution of stromal PEDF to cancer evolution is poorly understood. Therefore, we investigated the role of fibroblast-derived PEDF in melanoma progression. We demon...

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Vydáno v:Cancer Res
Hlavní autoři: Nwani, Nkechiyere G, Deguiz, Maria L, Jimenez, Benilde, Vinokour, Elena, Dubrovskyi, Oleksii, Ugolkov, Andrey, Mazar, Andrew P, Volpert, Olga V
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873437/
https://ncbi.nlm.nih.gov/pubmed/26921338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2468
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