Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic activity in a broad range of tumor types. Melanocytes and low aggressive melanoma cells secrete high levels of PEDF, while its expression is l...

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Detalhes bibliográficos
Main Authors: Fernández-Barral, Asunción, Orgaz, José Luis, Gomez, Valentí, del Peso, Luis, Calzada, María José, Jiménez, Benilde
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311626/
https://ncbi.nlm.nih.gov/pubmed/22457728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032989
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