Applying Small Molecule Signal Transducer and Activator of Trancription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics

Constitutively activated Signal Transducer and Activator of Transcription 3 (STAT3) protein has been found to be a key regulator of pancreatic cancer and a target for molecular therapeutic intervention. In this study PG-S3-001, a small molecule derived from the SH-4-54 class of STAT3 inhibitors, was...

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Publicado no:Mol Cancer Ther
Main Authors: Arpin, Carolynn C., Mac, Stephen, Jiang, Yanlin, Cheng, Huiwen, Grimard, Michelle, Page, Brent D. G., Kamocka, Malgorzata M., Haftchenary, Sina, Su, Han, Ball, Daniel, Rosa, David A., Lai, Ping-Shan, Gómez-Biagi, Rodolfo F., Ali, Ahmed M., Rana, Rahul, Hanenberg, Helmut, Kerman, Kagan, McElyea, Kyle C, Sandusky, George E., Gunning, Patrick T., Fishel, Melissa L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4873422/
https://ncbi.nlm.nih.gov/pubmed/26873728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0003
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