Caricamento...

Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization

The activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) is dysregulated in a number of hematological and solid malignancies. Development of pharmacological STAT3 Src homology 2 (SH2) domain interaction inhibitors holds great promise for cancer therapy, and...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Resetca, Diana, Haftchenary, Sina, Gunning, Patrick T., Wilson, Derek J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239608/
https://ncbi.nlm.nih.gov/pubmed/25288792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595454
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !